- PEG-DSA is primarily associated with LNP (elution peak at 15 min), while PEG-DMG is primarily associated with serum lipoproteins (eluents between 20 and 45 min) after 30 min incubation in rat serum.
- Degradation near or below the lower specification limits were induced for the drug substance and three of the four lipid components; PEG2000-C-DMG was resistant to degradation within the parameters studied.
Peg Derivatives
Peg Dmg 3
The zeta potentials of adriamycin-encapsulating liposomes containing 1-(monomethoxy polyethyl-eneglycol)-2,3-dimyristoylglycerol (PEG-DMG) were measured in an isotonic solution of 10mM lactate buffer (pH 4.0) with sodium chloride and sucrose. Download mac os el capitan dmg google drive. The negativity of the zeta potentials of adriamycin-encapsulating liposomes containing PEG-DMG decreased with increases in NaCl concentration more steeply than that of adriamycin-encapsulating liposomes without PEG coating. Dmg mori seiki winterthur jobs. From this observation, the electrical potential distributions near the membrane surfaces were shown to be different between adriamycin-encapsulating liposomes with and without PEG coating. Based on these zeta potential data, the thickness of the fixed aqueous layer around PEG-DMG-containing adriamycin liposomes was determined from the slope of In zeta potential versus Debye-Hiickel parameter plot. As a result, a correlation was indicated to exist between the circulation time of liposomes and the thickness of the aqueous layer around the liposomes.